CHOC Docs :: Provider Profile

Michele B Domico, MD


Critical Care

Board Certified:
Pediatrics, Critical Care Medicine


Dr. Domico is on staff at CHOC Children's Hospital & CHOC Children's at Mission Hospital

CHOC Children's Hospital
1201 W. La Veta Ave.
Orange, CA 92868
map & directions

CHOC Children's at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691
map & directions

Hoag Memorial Presbyterian Hospital
1 Hoag Dr
Newport Beach, CA 92663
map & directions

Physician Bio

Dedicated to her field, Dr. Domico provides the full range of critical care procedures, with expertise in pediatric cardiac intensive care. She has published several clinical research articles, including studies on extracorporeal life support and research related to cardiac intensive care. She has spearheaded multiple quality improvement projects in the cardiac intensive care unit at CHOC to ensure improved patient safety and outcomes. She also serves as a reviewer for Pediatric Critical Care Medicine journal.

Dr. Domico is board certified in both pediatrics and pediatric critical care medicine. Dr. Domico worked in London at the world-renowned Great Ormond Street Hospital for Children as a Senior Fellow in pediatric cardiac intensive care/ ECMO. She completed her pediatric critical care fellowship at Harbor-UCLA Medical Center and Children's Hospital of Orange County. She received additional fellowship training in pediatric cardiology at the University of Florida Health Science Center. Dr. Domico attended medical school and completed her internship and residency at University of Texas Health Science Center in San Antonio. She is currently the Medical Director of the Cardiac Intensive Care Unit at CHOC, and the Medical Director of the ECMO program.

Administrative Appointments

  • Critical Care, CHOC Children's Specialists

Academic Appointments

  • Assistant Clinical Professor, Pediatrics
    Harbor-UCLA Medical Center
  • Assistant Clinical Professor, Pediatrics
    University of California, Irvine Medical Center


  • Medical School
    University of Texas Health Science Center
  • Residency
    University of Texas Health Science Center
  • Fellowship
    University of Florida Health Science Center
    Harbor-UCLA Medical Center/Children’s Hospital of Orange County
    Great Ormond Street Hospital for Children

Board Certifications

  • Pediatrics
    American Board of Pediatrics
  • Critical Care Medicine
    American Board of Pediatrics

Honors and Awards

  • 2015 Physician of Excellence
    Orange County Medical Association
  • 2014 Physician of Excellence
    Orange County Medical Association

Professional Organizations

  • Pediatric Cardiac Intensive Care Society
  • Society of Critical Care Medicine
  • American Academy of Pediatrics


  • Extracorporeal Life Support Organization Research Grant Award
    Principal investigator: Predictors of Outcome for Pertussis patients on ECMO

Published Works

Domico M, Herrera M: Chapter 1 CICU Quick Reference. In: Pediatric Cardiac Intensive Care Handbook. Jones M, Klugman D, Fitzgerald R, Kohr LM, Costello JC, Berger, JT, Bronicki R. 1st edition. Washington, DC; 2015

Domico M, Hunt J, Anas N. Parenteral hypotonic saline prescribing frequency in a tertiary care children’s hospital. Pediatric Critical Care Medicine 2014; 15: 4(s) 201

Domico, M, BNP predicting outcome after congenital heart surgery: Are we there yet? Pediatric Critical Care Medicine 2013; 14: 550-551

Domico M, Brown K: Time to Initiating Extracorporeal Life Support May Be Lengthening From Duration on Mechanical Ventilation, But Interhospital Transport May Still Need to Occur Early. Ped Crit Care Med 2013; 14:113-114

Domico M, Ridout D, Bronicki R, Anas N, Cleary J, Cappon J, Goldman A, Brown K: The impact of mechanical ventilation time prior to the initiation of ECLS on survival in pediatric respiratory failure: A review of the ELSO Registry. Pediatric Critical Care Medicine 2012; 13:16-21

Domico, M, Checchia P: Biomonitors of cardiac injury and performance: B-type natriuretic peptide and troponin as monitors of hemodynamics and oxygen transport balance. Pediatric Critical Care Medicine 2011; 12: 33-42 (suppl)

Bronicki R, Herrera M, Mink R, Domico M, Tucker D, Chang A, Anas N: Hemodynamics and Cerebral Oxygenation following repair of Tetralogy of Fallot: The Effects of Converting from Positive Pressure Ventilation to Spontaneous Breathing. Congenital Heart Disease 2010; 5:416-421

Lectures and Presentations

  • Original Research/ Grant Awarded Invited Oral Presentation “Pertussis and ECMO: New predictors of Outcome”
    26th Annual ELSO Conference Atlanta, Georgia
  • “Ductal dependent circulation and Qp/Qs”
    NeoHeart 2015 Huntington Beach, California
  • “Biomarkers: What do they tell us that we don’t already know?”
    Pediatric Cardiac Intensive Care Society Meeting Miami, Florida
  • “Challenging Cardiac ICU cases”
    Pediatric Critical Care Colloquium Huntington Beach, California
  • “How to approach the most controversial ECMO patients”
    CHOC ECMO Conference Orange, California
  • “What biomarkers can help us in the Cardiac Intensive Care Unit”
    Pediatric Cardiac Intensive Care Society Meeting Miami, Florida

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UC Irvine

CHOC Children's is affiliated with the UC Irvine School of Medicine