CHOC Children's Specialists
505 S. Main Street
Orange, CA 92868
map & directions
CHOC Children's Hospital
1201 W. La Veta Ave.
Orange, Ca 92868-3874
map & directions
CHOC Children's at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691
map & directions
Internationally-recognized as an expert in the field of pediatric cardiology, Dr. Chang leads pediatric heart teams all over the world. He was one of the founding members of the Asia-Pacific Pediatric Cardiac Society (APPCS) and will be initiating the foundation arm of the society at the bequest of the board. Dr. Chang has been voted Physician of Excellence by the Orange County Medical Association and also selected as one of America’s Top Doctors, Top Pediatricians, and Best Cardiologists by several organizations.
A world-renown leader in pediatric cardiology innovation, Dr. Chang is a member of the grant review committee for pediatric research at the National Institutes of Health. Respected in his field, he is a member the board of directors for the American Heart Association. Providing leadership in education, he has served with the faculty of UCLA School of Public Health (eMPH program) and has taught global health for UCLA’s eMPH. He also teaches pediatric cardiology to cardiology fellows and holds a volunteer faculty appointment at the UCLA School of Medicine..
A prolific author, Dr. Chang is the chief editor of the textbook Pediatric Cardiac Intensive Care and the past president-elect of the Pediatric Cardiac Intensive Care Society (PCICS). He is the chief editor of the textbook Heart Failure in Children and Young Adults. He is an associate editor of Pediatric Critical Care Medicine and is on the editorial board of cardiology in the Young and Congenital Heart Today. He is a regular reviewer for Circulation, Pediatric Critical Care Medicine, Critical Care Medicine, and numerous other journals. He publishes and lectures widely on topics of pediatric cardiac intensive care, heart failure, sudden cardiac death, adult congenital heart disease, and other aspects of congenital heart disease. He has served as program director for numerous large international conferences and symposia.
With more that 20 years of experience, Dr. Chang’s responsibilities have included serving as a staff cardiologist at Boston Children’s Hospital with a position in the cardiac intensive care unit where he was later promoted to assistant professor at Harvard School of Medicine. He was later the medical director of the cardiac intensive care programs at Children’s Hospital of Los Angeles and Miami Children’s Hospital. He is also formerly the medical director of pediatric cardiac intensive care service and chief of critical care cardiology at Texas Children’s Hospital and a tenured associate professor at Baylor College of Medicine.
Dedicated to clinical excellence, Dr. Chang is board certified in pediatric cardiology. Prior to joining CHOC Children’s, Dr. Chang attended medical school at Georgetown University Medical School in Washington, D.C. He completed his residency training in pediatrics at Children’'s Hospital National Medical Center in Washington, D.C. and served his fellowship in cardiology at Children’s Hospital of Philadelphia. Dr. Chang has a master’s degree in healthcare administration from University of Miami School of Business, from which he graduated with the McGaw Prize for academic excellence. He has a master’s degree in public health from UCLA, from which he graduated with the Dean’s Award for academic excellence. He is enrolled in the master’s in biomedical informatics (MS-BMI) program at Stanford University.
Stapleton GE, Eble BK, Dickerson HA, Andropoulos DB, and Chang AC.
Mesenteric oxygen desaturation in an infant with congenital heart disease and necrotizing enterocolotis.
Texas Heart Institute Jounal 2007; 34:442-4.
Rossano JW, Smith EO, Fraser Jr. CD, McKenzie ED, Chang AC, Hemingway A,Price JF, Dickerson HA, and Mott AR.
Adults undergoing cardiac surgery at a children’s hospital: an analysis of perioperative morbidity.
Annual of Thoracic Surgery 2007; 83:606-12.
Tan LH, Jefferies JL, Liang JF, Denfield SW, Dreyer WJ, Mott AR, Grenier MA, Dickerson HA, Price JF, Towbin JA, Ou CN, and Chang AC.
Concentrations of brain natriuretic peptide in the plasma predicts outcomes of treatment of children with decompensated heart failure admitted to the Intensive Care unit.
Cardiology in the Young 2007; 17:397-406.
Tan LH, and Chang AC
Transhepatic approach as an alternative long-term central venous access in critically ill children with complex congenital heart disease: a new angle to an old problem
Pediatric Critical Care Medicine 2007; 8:298-9.
Tan LH, Hess B, Diaz LK, Cassady CI, Xu AM, Di Chiara L, Fraser CD, Andropoulos D, Chang AC, and Seidel FG.
Survey of the use of peripherally inserted central venous catheters in neonates with critical congenital cardiac disease.
Cardiology in the Young 2007; 17:196-201
Suominen PK, STayer S, Wang W, and Chang AC.
The effect of temperature correction of blood gas values on the accuracy of end-tidal carbon dioxide monitoring in children after cardiac surgery.
American Society for Artificial Internal Organs Journal 2007; 53:670-4.
Kuzin JK, Yborra JG, Taylor MD, Chang AC, Altman CA, Whitney GM, and Mott AR.
Family-member presence during interventions in the intensive care unit: Perceptions of pediatric cardiac intensive care providers.
Pediatrics 2007; 120:895-901.
Jeffries JL, Price JF, Denfield SW, Chang AC, Dreyer WJ, McMahon CJ, Grenier MA, Clunie SK, Thomas A, Moffett BS, Wann TS, Smith EO, and Towbin JA.
Safety and efficacy of nesiritide in pediatric heart failure.
Journal of Cardiac Failure 2007; 13:541-8.
Breinholt JP, fraser CD, Dreyer WJ, Chang AC, O’Brian Smith E, Heinle JS, Mckenzie E, Clunie SK, Towbin JA, and Denfield SW.
The efficacy of mitral valve surgery in children with dilated cardiomyopathy and severe mitral regurgitation.
Pediatric Cardiology 2008; 29:13-8.
Price JF, Mott AR, Dickerson HA, Jefferies JL, Nelson DP, Chang AC, O’ Brian Smith E, Towbin JA, Dreyer WJ, Denfield SW, and Goldstein SL.
Worsening renal function in children hospitalized with decompensated heart failure: evidence for a pediatric cardiorenal syndrome
Pediatric Critical Care Medicine 2008; 9:279-84.
Falkensammer CB, Heinle JS, and Chang AC.
Serial plasma BNP levels in assessing inadequate left ventricular decompression on ECMO.
Pediatric Cardiology 2008; 29-808-11.
Johnson, BA, and Chang AC.
Near-infrared spectroscopy and tissue oxygenation: the unremitting quest for the holy grail.
Pediatric Critical Care Medicine 2008; 9:123-4.
McCanta AC, Chang AC, and Weiner K.
Cardiomyopathy in a child with neutropenia and motor delay.
Current Opinion Pediatrics 2008; 20:605-7.
LaRovere JM, Jeffries HE, Sachdeva RC, Rice TB, Wetzel RC, Cooper DS, Bird GL, Ghanayem NS, Checchia PA, Chang AC, and Wessel DL.
Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease-the perspective of critical care.
Cardiology in the Young 2008; Suppl 2:130-6.
Li SC, Wang L, Jiang H, Acevedo J, Chang AC, and Loudon WG.
Stem cell engineering for treatment of heart diseases: potentials and challenges.
Cell Biology International 2009; 35:120-3.
Suesaowalak M, Cheung MM, Tucker D, Chang AC, Chu J, and Arrieta A.
Chlamydophila pneumoniae myopericarditis in a child.
Pediatric Cardiology 2009; 30:336-9.
Magliola R, Moreno G, Vassallo JC, Landry LM, Althabe M, Balestrini M, Charroqui A, Salgado G, Lataza E, and Chang AC.
Levosimendan, a new inotropic drug: experience in children with acute heart failure
Archivos Argentines de Pediatria 2009; 107:139-45
Chang AC, and Macrae D.
Neonates with congenital cardiac defects and pulmonary hypertension.
Cardiology in the Young 2009; Suppl 1:4-7.
Suesaowalak M. Cleary JP, and Chang AC.
Advances in diagnosis and treatment of pulmonary arterial hypertensionin neonates and children with congenital heart disease.
World Journal of Pediatrics 2010; 6:13-31.
Bronicki RA, Herrera M, Mink R, Domico M, Tucker D, Chang AC, and Anas G.
Hemodynamics and cerebral oxygenation following repair of Tetralogy of Fallot: the effects of converting from positive pressure ventilation to spontaneous breathing.
Congenital Heart disease Journal 2010; 5:416-21.
Bronicki RA, and Chang AC.
Management of postoperative pediatric cardiac surgical patient.
Critical Care Medicine 2011; 39:1974-84.
Quality and safety in the pediatric cardiac intensive care unit: it is time to leave the pit stop and the cockpit and perfect the handover.
Pediatric Critical Care Medicine 2011; 12:361-2.
Li SC, Acevedo J, Schwartz PH, Wang L, Jiang H, Luo J, Pestell RG, Loudon WG, and Chang AC.
Mechanisms for Progenitor Cell-mediated Repair for Ischemic Heart Injury.
Current Stem Cell Research Therapy 2010.
Lee GJ, Cohen R, Chang AC, Cleary JP.
Angiotensin Converting Enzyme Inhibitor (ACEI) “ Induced Acute Renal Failure in Premature Newborns with Congenital Heart Disease.
Journal of Pediatric Phamacology and Therapeutics 2010 Oct;15(4):290-6.
Tan LH, Du LZ, Carr MR, Kuzin JK, Moffett BS, and Chang AC.
Captopril induced reversible acute renal failure in a premature neonate with double outlet right ventricle and congestive heart failure.
World Journal of Pediatrics 2011; 7:89-91.
Primary prevention of sudden cardiac death of the young athlete: the controversy about the screening electrocardiogram and its innovative artificial intelligence solution.
Pediatric Cardiology 2012; 33:428-33.
Determination of cardiac output in critically ill children: are we any closer to the ideal methodology
Pediatric Critical Care Medical 2012; 13:99.
Chang AC, Morell J, Rebolledo M.
Ten Innovative Concepts for the Pediatric Cardiology Clinical Service.
Congenital Cardiology Today, May 2012.
Chang AC, Musen M.
Artificial Intelligence in Pediatric Cardiology: An Innovative Transformation In Patient Care, Clinical Research, and Medical Education.
Congenital Cardiology Today, November 2012.