CHOC Docs :: Provider Profile

Mary L Zupanc, MD



Child Neurology
Clinical Neurophysiology

Board Certified:
Pediatrics, Neurology with Special Qualifications in Child Neurology, Clinical Neurophysiology, Epilepsy

Dr. Zupanc is on staff at CHOC Children's Hospital & CHOC Children's at Mission Hospital

CHOC Children's Neuroscience Center
505 S Main St
Suite 350
Orange, CA 92868
phone: 888-770-2462
fax: 855-246-2329
map & directions

CHOC Children's Hospital
1201 W La Veta
Orange, CA 92868
map & directions

Physician Bio

As one of the country’s most highly regarded pediatric epileptologists, Dr. Zupanc has been instrumental in the development of comprehensive pediatric epilepsy programs at Mayo Clinic, Columbia University, and NYU School of Medicine. Dr. Zupanc is highly esteemed for her scholarship and contributions to the advancement of pediatric neurology. She has presented at numerous nationally and internationally recognized lecture series, and is a much sought speaker.

A internationally recognized expert, Dr. Zupanc has published many articles in peer reviewed journals, most notably the Journal of Pediatric Neurology, regarding pediatric epilepsy surgery and outcomes, the efficacy of Felbamate, and infantile spasms. Dr. Zupanc is the author of 15 textbook chapters including the chapter on epilepsy surgery in the field’s primary textbook, Pediatric Neurology. 

Dedicated to clinical excellence, Dr. Zupanc is board certified in pediatrics by the American Board of Pediatrics and in child neurology by the American Board of Psychiatry and Neurology. She is board certified in clinical neurophysiology by both the American Board of Psychiatry and Neurology and the American Board of Clinical Neurophysiology. Dr. Zupanc received her medical degree at UCLA, graduating first in her class. She completed pediatric residency at the University of Washington and her pediatric neurology fellowship at the University of Wisconsin. She has had additional training in advanced epilepsy at the University of Wisconsin, UCLA, and Stanford University.

Highly regarded for her expertise, Dr. Zupanc has received numerous awards for teaching recognition and clinical care at each of the major institutions she has served.

Administrative Appointments

  • Chair, Neurology, CHOC Children's
  • Director, Pediatric Comprehensive Epilepsy Program, CHOC Children's
  • Division Chief, Neurology, CHOC Children's Specialists

Academic Appointments

  • Clinical Professor, Department of Pediatrics, UC Irvine


  • Pediatrics Residency
    University of Washington School of Medicine, Children's Orthopedic Hospital, Seattle, WA
  • Pediatrics Residency
    Harbor-UCLA Medical Center, Torrance, CA
  • Child Neurology Fellowship
    University of Wisconsin Hospitals and Clinics, Department of Pediatrics and Neurology, Madison, WI
  • Neonatal EEG
    Stanford University, California
  • Magnetoencephalography, Surgical Treatment of Epilepsy
    University of California, Los Angeles (UCLA)

Board Certifications

  • Pediatrics
    American Board of Pediatrics
  • Neurology with Special Qualifications in Child Neurology
    American Board of Psychiatry & Neurology
  • Clinical Neurophysiology
    American Board of Psychiatry & Neurology
  • Epilepsy
    American Board of Psychiatry & Neurology

Professional Organizations

  • Epilepsy Foundation of America
  • American Medical Women's Association
  • American Medical Association
  • American Academy of Pediatrics
  • American Academy of Neurology
  • American Board of Psychiatry and Neurology
  • Child Neurology Society
  • American Epilepsy Society
  • Physicians for Social Responsibility
  • International Physicians for the Prevention of Nuclear War

Editorial Boards

  • Pediatric Neurology (Journal)
  • Family Practice Recertification Journal
  • Current Pediatric Review

Published Works

Wheless, JW, Carmant, L, Bebin, M, Conry, JA, Chiron, C, Elterman, RD, Frost, M, Paolicchi, JM, Shields, W, Thiele, EA, Zupanc, ML, Collins, SD: Magnetic Resonance Imaging Abnormalities Associated with Vigabatrin in Patients with Epilepsy. Epilepsia, 2009; 50(2): 195-205.

Zupanc ML. Clinical evaluation and diagnosis of severe epilepsy syndromes of early childhood. J Child Neurol 2009 Aug; 24(8Suppl):6S-14S

Zupanc ML, dos Santos Rubio EJ, Werner R, Schwabe M: Epilepsy Surgery Outcomes - Quality of Life and Seizure Control at Children’s Hospital of Wisconsin. Pediatr Neurol 2010; 42:12-20.

Zupanc ML, Werner RR, Schwabe M. et al. Efficacy of felbamate in the treatment of intractable pediatric epilepsy. Pediatr Neurol 2010; 42:396-403

Glauser T, Craan A, Shinnar S, et al. Ethosuximide, valproic acid, and lamotrigine in Childhood Absence Epilepsy. N Engl J Med 2010 Mar 4; 362(9):790.

Lin JS, Lew SM, Marcuccilli CJ, Mueller WM, Matthews AE, Koop JI, Zupanc ML. Corpus callosotomy in multistage epilepsy surgery in the pediatric population. J Neurosurg Pediatr 2011 Feb; 7(2):189-200.

Lew SM, Matthews AE, Mueller WM, Zupanc ML. Forty consecutive hemispherectomies: evolution of technique, outcomes, complications, and lessons learned.  Annual Meeting of the American Society of Pediatric Neurosurgeons, February 2, 2011, J Neurosurg: Ped

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UC Irvine

CHOC Children's is affiliated with the UC Irvine School of Medicine