CHOC Docs :: Provider Profile

Nick G Anas, MD


Critical Care

Board Certified:
Pediatric Critical Care, Pediatric Pulmonology, Pediatrics

Dr. Anas is on staff at CHOC Children's Hospital & CHOC Children's at Mission Hospital

CHOC Children's Hospital
1201 W La Veta
Orange, CA 92868
map & directions

CHOC Children's at Mission Hospital
27700 Medical Center Rd
Mission Viejo, CA 92691
map & directions

Hoag Memorial Presbyterian Hospital
1 Hoag Dr
Newport Beach, CA 92663
map & directions

Physician / Researcher Bio

A recognized expert in pediatric critical care medicine with more than 25 years of experience, Dr. Nick Anas has served as director of CHOC’s pediatric intensive care unit (PICU) since 1991 and as its pediatrician-in-chief since 2009.

As director of the pediatric critical care program, Dr. Anas has built a team that treats children with acute, life-threatening illnesses and injuries. Dr. Anas has committed his career to developing and maintaining a critical care program at CHOC defined by clinical excellence, an uncompromising drive to provide state-of-the-art medicine for the children of Orange County, and a national reputation for leadership in academics and research.

Dr. Anas is a highly regarded leader who has served as a member of the CHOC Board of Directors and presently is a member of several boards, including CHOC Children's Specialists, the CHOC Health Alliance and the Orange County Ronald McDonald House. Dr. Anas is a clinical professor of pediatrics in the department of pediatrics, David Geffen School of Medicine at UCLA and is an associate clinical professor of pediatrics at UC Irvine School of Medicine.

A nationally recognized expert in the treatment of acute respiratory failure in children, Dr. Anas is an active member in the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), an international research consortium. CHOC’s PICU is a research center for a number of clinical trials addressing issues pertinent to critical illness and injury. On the forefront of critical care education and research, Dr. Anas has more than 80 publications in prestigious medical journals and is the author and editor of several textbooks devoted to pediatric critical care. He has received numerous teaching awards from the UCI-CHOC residents and the CHOC critical care fellows.

Dr. Anas completed his critical care and pulmonary medicine fellowship training at the University of Rochester School of Medicine following his pediatric residency and chief residency training at Dallas Children's Medical Center, Southwestern School of Medicine. He received his medical degree from West Virginia University and his undergraduate education at Duke University.

Dr. Anas is a member of many professional organizations, including the American Academy of Pediatrics (AAP), the Society of Critical Care Medicine, the American Thoracic Society and the AOA Honor Medical Society. He also serves on the editorial board of Pediatric Critical Care Medicine, the leading journal in his discipline.

A recipient of numerous honors and awards, Dr. Anas was named the 2014 Pediatrician of the Year from the California Chapter 4 (Orange County) AAP. He is also consistently named one of Orange County’s Physicians of Excellence by the Orange County Medical Association. Dr. Anas feels a strong personal responsibility to the children and parents of Orange County. He is frequently quoted, The responsibility of the CHOC Children’s critical care program is to make sure our parents sleep knowing that we are here to keep their children safe and in good health. 

Administrative Appointments

  • Pediatrician-In-Chief, CHOC Children’s
  • Medical Director, Pediatric Intensive Care Unit, CHOC Children’s
  • Chair, Critical Care Medicine, CHOC Children's
  • Critical Care, CHOC Children’s Specialist

Academic Appointments

  • Associate Clinical Professor, Pediatrics
    UC Irvine
  • Clinical Professor, Pediatrics
    David Geffen School of Medicine, UCLA


  • Medical School
    West Virginia University, Morgantown, W Virginia
  • Medical School - Intern
    Pediatrics, Univ. of Texas Southwestern Medical School
  • Medical School - Resident
    Pediatrics Univ. of Texas Southwestern Medical School
  • Fellowship
    Postdoctoral Fellow in Pediatric Pulmonology and Critical Care
    University of Rochester, School of Medicine, Rochester, New York

Board Certifications

  • Pediatric Critical Care
    American Board of Pediatrics
  • Pediatric Pulmonology
    American Board of Pediatrics
  • Pediatrics
    American Board of Pediatrics

Honors and Awards

  • 2014 Pediatrician of the Year, California Chapter 4 (Orange County) American Academy of Pediatrics (AAP)
  • The Best Doctors in Orange County
    Multiple years
  • UCLA Pediatric Board Review
    Course Lecturer
  • The Best Doctors in America
    Multiple years
  • CHOC Housestaff Teaching Award
    Multiple years
  • Editorial Board, Pediatric Critical Care
    Multiple years

Professional Organizations

  • American Academy of Pediatrics
  • American Thoracic Society
  • California Thoracic Society
  • Society of Critical Care Medicine
  • Orange County Medical Association

Editorial Boards

  • Journal of Pediatrics
  • Pediatric Pulmonology
  • Pediatrics
  • Critical Care Medicine
  • Chest
  • Pediatric Critical Care Medicine
  • British Medical Journal

Published Works

Do T, Chu J, Anas N: Fontan patient with plastic bronchitis treated successfully using aerosolized tissue plasminogen activator: A case report and review of the literature. Pediatr Cardiol 2009; 30: 352-355.

Bronicki R, Anas N: Cardiopulmonary Interaction. Pediatr Crit Care Med 2009; 10: 313-322.

Cvijanovich N, Shanley T, Anas N et al: Validating the genomic signature of septic shock. Physiol Genomics 2008; 34: 127-134.

Wong H, Cvijanovich N, Anas N et al: Identification of pediatric septic shock based on genome-wide expression profiling. BMC Medicine 2009; 7:34.

Wong H, Cvijanovich N, Anas N et al: Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med 2009; 37: 1558-1566.

Gabrail N, Sandler E, Anas N et al: Tropics I: A Phase III, Randomized Double Blind Placebo-Controlled Study of Tenecteplase for Restoration of Function in Central Venous Catheters. J Vasc and Interventional Radiology (submitted for publication).

Bronicki R, Herrera M, Anas N et al: Hemodynamics and cerebral oxygenation following repair of Tetralogy of Fallot: The effects of converting from positive pressure ventilation to spontaneous breathing Congenit Heart Dis 2010; 5:416-421.

McBride J, Anas N: Extracorporeal membrane oxygenation survivors and pulmonary function: Encouraging outcomes early in life. Pediatr Crit Care Med 2010; 12:223-224.

Randolph A, Guo CY, Anas N et al: Vitamin D deficiency is associated with mortality in patients admitted to the pediatric intensive care unit with community acquired influenza infection. JAMA (accepted for publication)

Perkin R, Anas N: Pulmonary artery catheters Pediatr Crit Care Med 2011; 12 (4): 512-20.

Wong H, Cvijonovich N, Anas N et al: Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med 2011; 39: 2511-2517.

Randolph A, Vaughn F, Anas N et al: Critically ill children during the 2009-2010 Influenza Pandemic in the United States. Pediatrics 2011; 39: 2511-2517.

Wynn J, Cvijonovich N, Anas N et al: The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med 2011; 1146-1156.

Kline A, Sorce L, Levin D, Anas N: Pulmonary Disorders in Nursing Care of the Critically Ill Child Hazinski M (Ed). Elsevier USA 2012; 483-561.

Domico M, Ridout D, Bronicki R, Anas N et al: The impact of mechanical ventilation time before initiation of extracorporeal life support on survival in pediatric respiratory failure: A review of the extracorporeal life support registry. Pediatr Crit Care Med 2012: 13:16-21.

Basu R, Stendage S, Anas N et al: Identification of candidate serum biomarkers for severe septic shock “ associated kidney injury via microarray. (Submitted for publication).

Wong H, Salibury S, Cvijanovich N et al: The pediatric sepsis biomarker risk model. Critical Care 2012. 16:174

Lectures and Presentations

  • Pediatrician-in-Chief “ Children’s Hospital of Orange County and UCI Irvine Department of Pediatrics 2009.
  • Pulmonary artery catheters: State of the art. Pediatric Cardiac Intensive Care Society 2010
  • Pediatric representative to the Sepsis Advisory Committee. Society of Critical Care Medicine 2010.
  • Appointed to Editorial Board: Pediatric Critical Care Medicine 2010.
  • Cardiopulmonary Interactions: Pediatric Critical Care Board Review Course 2011.
  • President, Children’s Specialty Care Coalition Board of Directors 2012.
  • Board of Directors, Orange County Ronald McDonald House 2012.

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UC Irvine

CHOC Children's is affiliated with the UC Irvine School of Medicine